The story follows two brothers (Sam and Dean Winchester) who are out to kill every evil thing in this world. When Dean was 4 yrs old and Sam only 6 months old; their mother (Mary) was killed, their father (John) was determined to find and kill the demon who killed his wife. Raising the boys as "HUNTERS" of all things evil. Their motto: SAVING PEOPLE, HUNTING THINGS, THE FAMILY BUSINESS. After John's death the boys continue the family business with the help of a few other hunters, traveling cross country, killing as many monsters as possible and saving as many people as they can. And at the same time they learn that "Family don't end with blood". They will do whatever it takes to save each other and their "FAMILY". Going up against demons, vampires, werewolves, shapshifters, demigods, witches, the four horsemen and even angels among other things. They lose family and find new people they call family. They have gone to heaven and hell for each other and will do it all over again. Cause that's what FAMILY does and "Family don't end with blood".